Low cholesterol targets cut cardiovascular events by 33%

Posted by brandonb 6 hours ago

Counter14Comment7OpenOriginal

Comments

Comment by brandonb 6 hours ago

The 55 mg/dL target in this study is somewhere between the 1st and 5th percentile.

70 mg/dL (the control) is around the 10th percentile.

IMO, surprising that reductions at the low end still seem to yield such large benefits. I'd expect it to saturate much earlier.

Comment by jvanderbot 2 hours ago

Outlive is an excellent book, and one of the excellent discussions in that book is that there is no safe level of certain kinds of cholesterol. The details are fun do read up on.

It's somewhat bombastic, but a really excellent book for overall "next generation" health.

Comment by yfw 59 minutes ago

He also recommends people take rapamycin for longevity...

Comment by esperent 26 seconds ago

[delayed]

Comment by DANmode 2 hours ago

Perhaps cholesterol is a (protective?) substance associated with a problem,

not the problem in and of itself.

Comment by 4 hours ago

Comment by westurner 3 hours ago

ScholarlyArticle: "Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease" (2026) https://www.nejm.org/doi/full/10.1056/NEJMoa2600283

Comment by westurner 3 hours ago

Do they control for arterial calcification?

Mentioning this again: Cyclodextrin apparently effectively treats atherosclerosis and arteriosclerosis. [1][2]

[1] "AI analysis of CT scans finds 42.9% of patients have coronary inflammation" https://news.ycombinator.com/item?id=50202532 :

> Can Beta-Cyclodextrin treat (calcified) atherosclerotic plaques? And gout?

> What percentage of cardiovascular "plaque" is sugar alcohol and thus apparently treatable with β or α cyclodextrin, in controls and patients with conditions like Arteriosclerosis and Atherosclerosis?

[2] "Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming" (2016) https://www.science.org/doi/10.1126/scitranslmed.aad6100

Comment by westurner 3 hours ago

Do steak and pork from Cheesecake Factory have cholesterol?

Comment by aaron695 4 hours ago

[dead]