Moderna and Merck say their mRNA cancer vaccine cut death, recurrence by 42%
Posted by _Microft 3 days ago
Comments
Comment by wrs 3 days ago
Comment by pavlov 3 days ago
People like Marc Andreessen, Larry Ellison and Elon Musk are actively supporting the administration, including hundreds of millions in donations to MAGA political campaigns in recent months.
Should we hold these people accountable for the damage they're indirectly doing to public health? If not, why?
Comment by nfw2 3 days ago
That said:
1. Funding hasn't been pulled for mrna vaccines for cancer. rfk has been equivocal about the topic. NCI is stilling rewarding grants for mrna-vaccine cancer trials.
2. Pulling funding is different from blocking vaccines from reaching the market. The new season's covid vaccine is presumably an mrna vaccine. For cancer vaccines, it would be very strange to fund a vaccine just to block it from the market.
Should we hold these people accountable?
What do you mean? The court of public opinion seems to hold them accountable. Are you proposing legal punishments for Marc Andreessen? For what specifically?
Comment by lokar 3 days ago
Comment by soon_to_be_sb 3 days ago
Why though? Would they get paid by "crakpots" more than they could get paid by Big pharma !?
Apparently everyone knows Trump is only interested in him and friends making money. So how do you rationalize your claim?
Comment by ceejayoz 3 days ago
Yes. A whole bunch of the prominent "MAHA" folks sell/promote supplements, peptides, miracle cures.
https://en.wikipedia.org/wiki/Children's_Health_Defense
https://www.cspi.org/press-release/peptides-fda-urged-overru...
https://www.washingtonpost.com/health/2024/12/03/dr-oz-influ...
There's a shitload of money in alternative medicine, and you can get away with more.
Comment by soon_to_be_sb 3 days ago
Comment by ceejayoz 2 days ago
Does he seem like the sort big pharma would go "yes, fund that guy, great spokesperson!" Someone who endorses misama theory over germ theory? https://www.npr.org/sections/shots-health-news/2025/06/14/nx...
Comment by soon_to_be_sb 1 day ago
You can say that they are really wrong. But then it becomes a subjective thing...
Comment by soon_to_be_sb 1 day ago
I mean, you can say that they truly believe in what they are trying to do, but they are very wrong (and stupid). But then it becomes a subjective thing...
Comment by ceejayoz 19 hours ago
Comment by soon_to_be_sb 19 hours ago
Comment by ceejayoz 18 hours ago
Comment by soon_to_be_sb 14 hours ago
Comment by maram 3 days ago
How much did Moderna and Pfizer profit from the vaccines? I always go back to PG’s 2020 tweet: “Anyone else notice Fauci seems happier? I don’t think it’s just the vaccine.” https://x.com/paulg/status/1328075680492511232?s=46
Comment by poly2it 3 days ago
Comment by JumpCrisscross 3 days ago
Important? Yes. Relevant? No.
Comment by userbinator 3 days ago
Comment by sumeno 3 days ago
Comment by ceejayoz 3 days ago
Would you say the Trump administration still now supports that?
Comment by eeeeeeeeeeeee 3 days ago
Comment by jeromegv 3 days ago
Comment by jibalt 3 days ago
Comment by mikewarot 3 days ago
According to wikipedia, the mechanism they (the mRNA based treatments) use is:
In contrast, mRNA vaccines introduce a short-lived[58] synthetically created fragment of the RNA sequence of a virus into the individual being vaccinated. These mRNA fragments are taken up by dendritic cells through phagocytosis.[59] The dendritic cells use their internal machinery (ribosomes) to read the mRNA and produce the viral antigens that the mRNA encodes.[4] The body degrades the mRNA fragments within a few days of introduction.[60] Although non-immune cells can potentially also absorb vaccine mRNA, produce antigens, and display the antigens on their surfaces, dendritic cells absorb the mRNA globules much more readily.[61] The mRNA fragments are translated in the cytoplasm and do not affect the body's genomic DNA, located separately in the cell nucleus.[1][62]
So, it's a short lived, self limited gene therapy, not a vaccine. It hijacks the patients own cells to provoke an immune response. If the cells hijacked happen to be in tissue other than the intended injection site, via blood circulation, for example... you can (and sometimes do) have things like heart tissue being attacked by the immune system, with health altering results.We shouldn't let the category of vaccines include these treatments. It obscures informed consent in a manner that seems to border on deception for better marketing purposes.
Comment by strawhatguy 3 days ago
But I'll just say there's a reason why the phone app icon on smartphone is of a receiver, when fewer people have even seen one, and how it works is a bit different, despite the goal being the same.
We understand the new by comparisons to the existing.
Comment by gus_massa 2 days ago
[1] That is super safe, but the nurse ask if you or your family are taking inmunosupresants.
[2] That has other problems and is being phased out where possible.
[3] That has possible problems with the reuse of the vector.
Comment by Timon3 3 days ago
I also don't understand your larger objection. Your quote seems to say that the only difference compared to a regular vaccine is that the antigens are produced inside the patient's body, but the vaccination mechanism is literally the exact same. So why would you object to calling it a vaccine?
Comment by M95D 2 days ago
In case you don't know, the very first vaccine invented was the rabies vaccine. It also contained RNA - a live rabies virus - and it also hijacks the patients own cells to provoke an immune response.
Please stop spreading conspiracy theories.
Comment by cykros 3 days ago
Make 'em all you want, but call them what they are. Or don't be surprised when suddenly nobody wants to give their kids tetanus shots anymore because they can't trust anyone in the medical industry to give it to them straight.
Comment by M95D 2 days ago
Comment by zetazzed 3 days ago
Comment by CamelCaseName 3 days ago
To illustrate how much they've gone up, this 18% drop is just slightly less than their entire market cap in June (four months ago)
Comment by sneak 3 days ago
Like the FedEx logotype arrow, now I will never unsee it.
Comment by leoc 3 days ago
Comment by jeffybefffy519 3 days ago
Comment by ortusdux 3 days ago
Comment by bonsai_spool 3 days ago
The trial result is excellent - anyone ‘not convinced’ was not living in the realm of typical results.
Please note this has about nothing whatsoever to do with COVID. It’s probably best not to comment on technical topics if you have no relevant experience.
Comment by ortusdux 3 days ago
Comment by TaupeRanger 3 days ago
Comment by gault8121 3 days ago
The question now is what do you get with both treatments together?
Comment by machomaster 3 days ago
Comment by _Microft 3 days ago
https://www.biontech.com/int/en/home/pipeline-and-products/p...
Comment by reilly3000 3 days ago
Comment by JumpCrisscross 3 days ago
> lost my dad to cancer because of cancer medication
Please don’t phrase it like this. Loss is hard. But desperate people have skipped treatment because they misread something online.
Comment by reilly3000 3 days ago
That isn’t to say there aren’t terrible tradeoffs that have to be faced in the course of cancer treatment, and much of medicine. Pharmaceuticals seem to beget pharmaceuticals.
Comment by r_lee 3 days ago
that's great though that you got closure. also remember that hindsight is 20/20 and it's hard to really link some vague symptoms to a disaster until it's too late
Comment by JumpCrisscross 3 days ago
Comment by DANmode 3 days ago
I wish we were better at having the hard conversations beforehand,
(regarding metabolic health, immune health, what those even mean, why they apply).
Comment by sfink 3 days ago
I don't mind the above wording at all, because there's another thing that happens: people seem to have this impression that if you get cancer, follow the recommended treatment, and are in remission... that you're "done", and you "won". It isn't like that. First, the treatments have serious side effects, both short and long term. Second, cancer is never gone from your life, even if it never comes back. That doesn't mean you should not do the recommended and available treatments. Your odds of survival are almost always much much higher if you do, and imo is the right thing to do for the vast majority of people. But go into it with your eyes open. You're past the point where you get to have a conventional happy ending. You'll need to figure out how to be ok with the ending that you can still have. (Which may be a happy one! But not in the way that you imagined when you were younger.)
Comment by boothby 3 days ago
Comment by pmarreck 3 days ago
Comment by cykros 3 days ago
Dying once is bad, but based on what I've read about the second death, it's even worse.
Comment by Viliam1234 1 day ago
Comment by londons_explore 3 days ago
If you hold the key to saving a million people's lives, yet you decide to let those million people die so you can take the stage at a prestigious conference, are you a good person?
Curing disease is literally a race, with people dying every minute of every day. In any other situation, labs would be running night and weekend shifts and not a second would be lost.
Comment by estearum 3 days ago
It takes a profoundly naive person to think an organization full of people who have literally dedicated their careers to actually solving these problems are focused on the prestigious conferences.
These people signed up for decades and decades of work on a problem that would result in (statistically speaking) guaranteed failure.
Comment by fourteenrhinos 3 days ago
In practice, data for new cancer treatments is usually published 6-12 months before approval. There are definitely exceptions, especially where the drug is already approved and the data is supporting a new use, but that is not the norm for new drugs.
There are other factors too e.g. it can take time to make commercial drug supply available. In this specific case how Merck/Moderna will scale the boutique manufacturing process for a much larger number of patients while maintaining the speed they need for the treatment to work is a major question.
Again, the company is extremely motivated to do all of this as fast as possible. In addition to the points raised elsewhere in this chain.